The present invention relates to an auto-injection device (100) repeatedly activateable for automatically expelling multiple set doses of a liquid drug. An activation button (190) protrudes from a proximal end of a housing (101) and is axially moveable between an activateable position and an activated position. The auto-injection device includes dose setting means comprising a dose setting device (170) that performs a helical movement away from a zero dose position during setting of a dose and returns by a helical movement to the zero dose position as the set dose is expelled. The dose setting device (170) is coupled to the activation button (190) to retain the activation button in the activated position when the dose setting device (170) assumes its zero dose position.
