#$%^&*AU2018211208A120180816.pdf#####INSULIN RECEPTOR PARTIAL AONISTS Abstract 0.69 nmol/kg, iv 0 0 I0 120 10 240 W 30 420 480 Time (min) -- 0--- Dim~er 40 -- O D~mr 24 5 FIG.1 _ ae1,18 Insulin diners and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.