Extracts derived from plants of the Tsuga genus having anti-inflammatory and anti-microbial properties are provided. The Tsuga extracts are suitable for the treatment of inflammation, irritation and/or infection. For example, for the treatment of dermatological conditions with an associated inflammatory component or infection； for combating the irritant or inflammatory effects of other skin treatment compounds； for combating the irritant or inflammatory effects of environmental factors； for treating obesity-related skin problems (for example, inflammation, redness, erythema, rashes and/or bacterial infections caused by skin folds)； for combating the irritant or inflammatory effects of, or infection due to, exfoliation, laser treatments or hair removal； for treating irritation, inflammation and/or infection associated with diaper rash； for incorporation into dermatological formulations for sensitive skins, and for providing a preservative effect to dermatological formulations, as well as for ameliorating the dermatological effects of ageing.
