MAGGI LORETTA,CAPONETTI GIOVANNI,BUTTI HEIKE,VENEZIANI CRISTINA,ZANELLOTTI LAURA
申请号：
IN201717014034
公开号：
IN201717014034A
申请日:
2017.04.20
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention relates to inhalation formulations of drugs in the form of dry powder for inhalation administration deliverable as such with an inhaler and provided with high deliverability respirability and stability. In particular the invention relates to a pharmaceutical composition for inhalation use in powder form comprising a first powder comprising at least a powder (a1) comprising an active agent or a pharmaceutically acceptable salt thereof in an amount greater than 1% by weight of the powder leucine in an amount from 5 to 70% by weight of said powder a sugar in an amount from 20 to 90%> by weight of the powder and a second powder comprising a mixture of a first lactose which has an X50 from 35 to 75 µm with a second lactose which has an X50 from 1.5 to 10 µm the content of the first and second lactose in the mixture are respectively from 85% to 96% and from 4% to 15%. The ratio by weight between the first powder and the second powder is from 1/5 to 1/100 and the composition has a fine particle fraction (FPF) greater than 60% and a delivered fraction (DF) greater than 85%.
