ANTICORPS HUMAINS ET SEQUENCES DE LIAISON SPECIFIQUES DE CEUX-CI A UTILISER POUR UN ACCIDENT VASCULAIRE CEREBRAL ET UNE ISCHEMIE OU DES ETATS ISCHEMIQUES
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人:
RODRIGUEZ, MOSES,WARRINGTON, ARTHUR E.,PEASE, LARRY R.
申请号：
CA2870625
公开号：
CA2870625A1
申请日:
2013.04.17
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Specific binding members, particularly human antibodies, particularly recombinant antibodies, and fragments thereof, which are capable of binding to and recognizing neurons in the CNS and eliciting responses in CNS neurons are provided. The antibodies are useful in the diagnosis and treatment of conditions associated with nerve damage, injury or degeneration and neurodegenerative disease, and in particular in the treatment or alleviation of stroke or cerebral ischemia. The antibodies, variable regions or CDR domain sequences. thereof, and fragments thereof of the invention may also be used in therapy in combination with chemotherapeutics, immune modulators, or neuroactive agents and/or with other antibodies or fragments thereof. The antibodies or active fragments thereof may be used in therapy for stroke or cerebral ischemia alone or in combination with thrombolytics such as TPA. Antibodies are exemplified by the antibodies lgM12 and lgM42 whose sequences are provided herein.
