AGENTS PREVENTIFS OU REMEDES CONTRE LA MALADIE D'ALZHEIMER OU INHIBITEURS DE LA FIBROSE DES PROTEINES AMYLOIDES CONTENANT DES COMPOSES HETEROARYLE A TENEUR EN AZOTE
MEGURO, MASAKI,ODA, TOMIICHIRO,NAKAGAMI, YASUHIRO,MARUMOTO, SHINJI,KOYAMA, KAZUO,KANEKO, ISAO
申请号：
CA2468948
公开号：
CA2468948C
申请日:
2002.11.25
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to preventives or remediesfor Alzheimer's disease, or to amyloid proteinfibril--formation inhibitors, which include as an activeingredient a compound of general formula (I) below or apharmacologically permitted salt thereof； and also tonitrogen-containing heteroaryl derivatives havingspecific substituents, or pharmacologically permittedsalts thereof, which are valuable as preventives orremedies for Alzheimer's disease, or as amyloid proteinfibril-formation inhibitors:(see formula I)(where, R1 and R2 are H or alkyl； Z1 and Z2 are H, alkyl,alkoxy, haloalkyl or halogeno； Z3 is alkoxy, SH,alkylthio, NH2, mono- or di-alkylamino, OH or halogeno；Z4 and Z5 are H or halogeno； and A is4,6-pyrimidine--1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
