БЛАГОСКЛОННЫЙ Михаил В. (US),ГУДКОВ Андрей В. (US),ДЕМИДЕНКО Зоя Н. (US)
申请号：
RU2012122607/15
公开号：
RU2012122607A
申请日:
2010.11.04
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method of suppressing and / or slowing down the cellular aging of a mammal by contacting mammalian cells with a composition comprising a non-genotoxic p53 inducer (NGIP). The method according to claim 1, characterized in that NGIP is nutlin, an analog of nutlin, or a combination thereof. The method according to claim 2, characterized in that the mammalian cells are present in humans. The method according to claim 3, characterized in that the person has not been diagnosed with cancer. The method according to claim 4, characterized in that NGIP is nutlin-3A.6. The method according to claim 1, characterized in that NGIP is an Mdm binding agent or antagonist of Mdm-2.7. The method according to claim 4, characterized in that the suppression and / deceleration of cell aging in mammals includes the transition of mammalian cells to a resting state. The method according to claim 1, characterized in that NGIP induces p53 by blocking the interaction of p53 with other proteins. The method according to claim 3, characterized in that the person needs the prevention and / or treatment of age-related diseases selected from the group consisting of benign prostatic hyperplasia, angioma, cardiovascular diseases, atherosclerosis, hypertension, osteoporosis, insulin resistance and type II diabetes, disease Alzheimer's, Parkinson's disease, age-related macular degeneration, retinopathy, systemic lupus erythematosus, psoriasis, proliferation of smooth muscle cells and thickening of intima after vascular damage, inflammation, ar trit, side effects of chemotherapy, as well as their combination. 10. A method for reducing cellular hypertrophy in the body, comprising administering a therapeutically effective amount of a composition containing antihypertrophic1. Способ подавления и/или замедления клеточного старения млекопитающего путем контактирования клеток млекопитающего с композицией, включающей негенотоксичный индуктор p53 (NGIP).2. Способ по п.1, отличающийся тем, что NGIP представля
