Roger W. BEUERMAN,Shouping Liu,Jing Li,Lei Zhou,Chandra Shekhar Verma,Donald Tan
申请号：
US14090057
公开号：
US20140142027A1
申请日:
2013.11.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop composition, contact lens solution compositions for coating medical devices and the like. The invention also relates to the use of these multimeric forms of peptides, e.g. multimeric forms of defensin peptides for inhibiting and/or reducing the growth of microorganisms in general, including in a host. The invention further relates to a method of preparing multimers of peptides derived from defensins, for example hBD3. The method includes a composition or combination comprising the multimeric antimicrobial peptides and at least one active pharmaceutical ingredient.
