Федеральное государственное бюджетное учреждение науки Институт ядерной физики им. Г.И. Будкера Сибирского отделения РАН (ИЯФ СО РАН) (RU)
发明人:
Таскаев Сергей Юрьевич (RU),Каныгин Владимир Владимирович (RU),Мухамадияров Ринат Авхадиевич (RU),Кичигин Александр Иванович (RU)
申请号：
RU2014148670
公开号：
RU2014148670A
申请日:
2014.12.02
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method for delivery of boron-containing preparations for boron neutron capture therapy (BNCT) via liposomes, wherein the liposomes are produced, including boron-containing preparations, liposomes injected into the test organism or tissue, monitor delivery of boron-containing preparations, characterized in that in the manufacture of liposomes administered boron containing drugs in the lipid portion and the aqueous portion of the liposomes, a further portion of the liposome lipid administered luminescent dye of the same color in the aqueous portion of the liposomes - a luminescent rasitel another color, and control of delivery into the cell is performed by comparing the image obtained in this and in another color with the retaining ustroystva.2. A method of boron delivery of drugs for BNCT using liposomes according to claim. 1, characterized in that in the manufacture of liposomes pegiliruyut.3. A method of boron delivery of drugs for BNCT using liposomes according to claim. 1, characterized in that the fixing device using fluorescence microscope with appropriate filtrami.4. A method of boron delivery of drugs for BNCT using liposomes according to claim. 1, characterized in that as a dye introduced into the lipid portion of the liposome, using the dye from the group of lipophilic fluorescent dye, preferably PKH-26.5. A method of boron delivery of drugs for BNCT using liposomes according to claim. 1, characterized in that as a dye introduced into the aqueous portion of the liposomes used dye from the group of hydrophilic fluorescent dyes, preferably FITC-dekstran.6. A method of boron delivery of drugs for BNCT using liposomes according to claim. 1, characterized in that as Borso1. Способ доставки борсодержащих препаратов для бор-нейтронозахватной терапии (БНЗТ) с помощью липосом, при котором изготавливают липосомы, включающие борсодержащие препараты, вводят липосомы в исследуемый организм или в ткань, осуществляют контроль доставки борсодержащих препаратов, отлича
