Sophie Marie Combe-Marzelle,Sanjay Kumar Kakkar,Graham Douglas Allen
申请号：
US10592265
公开号：
US20120040904A1
申请日:
2005.03.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The use for the manufacture of a medicament for preventing unwanted coagulation during surgery, and particularly a Coronary Artery By pass Graft (CABG) procedure, of boronic acids of formula (I), and salts, prodrugs and prodrug salts thereof wherein Y comprises a moiety which, together with the fragment —CH(R9)—B(OH)2, has affinity for the substrate binding site of thrombin and R9 is a straight chain alkyl group interrupted by one or more ether linkages and in which the total number of oxygen and carbon atoms is (3, 4, 5) or (6) or R9 is —(CH2)m—W where m is (2, 3, 4) or (5) and W is —OH or halogen (F, CI, Br or I).
