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Gene silencing of the brother of the regulator of imprinted sites (BORIS)
专利权人:
发明人:
申请号:
EP13187262.4
公开号:
EP2682468A3
申请日:
2008.08.11
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention provides methods and compositions useful for inhibiting expression of the gene encoding the transcription factor, Brother of the Regulatory of Imprinted Sites (BORIS) by RNA interference. Methods of the present invention can be used to silence BORIS in cancer cells, which results in apoptosis and may be useful as for treating cancer in mammals. The methods of the invention directed to cancer therapy can be used alone or in combination with standard cancer treatments such as surgery, radiation, chemotherapy, and immunotherapy.
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