KANG, Heun-Soo,PARK, So-Hyun,SONG, Yeong Wook,SHIN, Ki Chul,LEE, Eun Young,LEE, Eun Bong,PARK, Young Woo,PARK, Bum-Chan,LEE, Dong Hee,KIM, Dong Jin,YUN, Seon Ha,LEE, Ke Se,LEE, Hyun Ju,KIM, Kyung Jin
申请号：
HK16111369.2
公开号：
HK1223112A
申请日:
2016.09.29
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The present invention relates to a TNF-± (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXCL10 specific antibody links to the C-terminus of the heavy chain constant domain of the TNF-± specific antibody, is a bispecific antibody that effectively binds to both TNF-± and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-±/CXCL10. A composition of the present invention comprises a TNF-±/CXCL-10 double targeting antibody which effectively binds to both TNF-± and CXCL10. The double targeting antibody of the present invention has excellent TNF-± inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-± or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease.
