Yun Yen,David Horne,Yate-Ching Yuan,Bing-Sen Zhou,Angela L Perkins Harki,Leila Su
申请号：
US13093389
公开号：
US08163783B2
申请日:
2011.04.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
