METHOD OF PREPARING VORTIOXETINE

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专利权人:

发明人:

KLVANA ROBERT,RADL STANISLAV,RICHTER JINDRICH

申请号：

IN201637043934

公开号：

IN201637043934A

申请日:

2016.12.22

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

The new method of preparing 1 (2 (2 4 dimethylphenylsulphanyl)pheny!)piperazine of formula (I) or its salt comprises a reaction of 2 (2 4 dimethylphenylsulphanyl)benzeneamine of formula (XI) wherein Me is methyl with a suitable precursor of formation of piperazine ring of formula (Xll) wherein LG is a leaving group and R is hydrogen or a protective group in a suitable organic solvent wherein the reaction is carried out without presence of a base in a neutral or acidic environment. (Formulae (I) (XI) (XII))

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中国工程科技知识中心

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