Three tier architecture for image-based diagnosis and monitoring application using Cloud is described. The presentation layer is run on the tablet (mobile device), while the business and persistence layer runs on a single cloud or distributed on different Clouds in a multi-tenancy and multi-user application. Such architecture is used for automated data mining application for computing (a) cardiovascular risk, stroke risk using IMT measurement, plaque characterization, (b) computing diagnostic index for benign vs. malignant tissue for ovarian cancer classification (c) benign vs. malignant tissue characterization for prostate cancer and (d) classification of fatty liver disease vs. normal cases. The Architecture is for data mining application.