Ústav Struktury A Mechaniky Hornin AV CR, V.V.I.;Ceské Vysoké Ucení Technické V Praze Fakulta Strojni;ProSpon spol. s.r.o.;Contipro a.s.
发明人:
申请号：
EP17197245.8
公开号：
EP3311854A1
申请日:
2017.10.19
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The subject of the invention is a bioactive nanocomposite layer prepared by the combination of electrospinning and electroblowing of a collagen solution comprising hydroxyapatite nanoparticles and poly(ethylene oxide), where, after the preparation and the crosslinking, the layer consists of 75 to 100 wt. % of collagen type I fibres, 5 - 15 wt. % of hydroxyapatite, and 0 - 1 wt. % of poly(ethylene oxide). The subject of this invention is also a method of production of said layer and a method of depositing antibiotics for a more effective releasing thereof without increasing the cytotoxicity. Said method comprises the impregnation of crosslinked sterilized collagen/hydroxyapatite layers with antibiotics in the form of a solution. The subject of the invention also comprises orthopaedic and dental implants based on metal or metal alloys, electrostatically coated with said composite layer based on collagen nanofibers with integrated hydroxyapatite nanoparticles and an antibiotic or a combination of antibiotics.
