3-hydrazinopyridine dihydrochloride is dialkylated with dialkyl maleate to provide alkyl 5-oxo-2-(pyridin-3-yl) pyrazolidine-3-carboxylate and chlorinated to give alkyl 3-Chloro-l-(pyridin-3-yl)-4,5-dihydro-lH-pyrazole-5-carboxylate, Carboxylate and converting the ester to the carboxylic acid by hydrolysis to give 3-chloro-l-(pyridin-3-yl)-lH-pyrazole-5-carboxylic acid 3-(3-chloro-lH-pyrazol-l-yl) pyridine is prepared by providing the hydrochloride and removing the carboxylic acid by decarboxylation.3-히드라지노피리딘·디히드로클로라이드를 디알킬 말레에이트로 고리화하여 알킬 5-옥소-2-(피리딘-3-일)피라졸리딘-3-카르복실레이트를 제공하고, 염소화하여 알킬 3-클로로-1-(피리딘-3-일)-4,5-디히드로-1H-피라졸-5-카르복실레이트를 제공하고, 산화시켜 알킬 3-클로로-1-(피리딘-3-일)-1H-피라졸-5-카르복실레이트를 제공하고, 에스테르를 가수분해에 의해 카르복실산으로 전환시켜 3-클로로-1-(피리딘-3-일)-1H-피라졸-5-카르복실산 히드로클로라이드를 제공하고, 카르복실산을 탈카르복실화 반응에 의해 제거함으로써 3-(3-클로로-1H-피라졸-1-일)피리딘을 제조한다.
