1R, 2S-Metoksamina i jej zastosowanie, kompozycja farmaceutyczna zawierająca 1R, 2S-Metoksaminę oraz sposób jej wytwarzania

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专利权人:

NORGINE EUROPE BV

发明人:

BARRAS NORMAN,NORMAN BARRAS,THOMPSON JEFFREY M.,JEFFREY M. THOMPSON

申请号：

PL369828

公开号：

PL217404B1

申请日:

2002.12.20

申请国别(地区):

PL

年份:

2014

代理人:

摘要：

A process for the production of 1R,2S-methoxamine, which comprises adding trifluoroacetic acid dropwise to a solution comprising (S)-amino-1-(2,5-dimethoxyphenyl)-1-propanone, the amino group of which is protected, and dimethylphenylsilane and removing the protecting group from the resulting amino-protected(1R,2S)-2-amino-1-(2,5-dimethoxy-phenyl)-1-propanol. Also claimed are 1R,2S-methoxamine or a physiologically tolerable salt thereof for use as a medicament, and a pharmaceutical composition comprising 1R,2S-methoxamine or a physiologically tolerable salt thereof in admixture or conjunction with a pharmaceutically suitable carrier.

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