REDUCTION OR ELIMINATION OF IMMUNE RESPONSES TO NON-INTRAVENOUS, E.G., SUBCUTANEOUSLY ADMINISTERED THERAPEUTIC PROTEINS

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专利权人:

ModernaTX; Inc.

发明人:

Luis Brito,Gilles Besin

申请号：

US16603111

公开号：

US20200109420A1

申请日:

2018.04.05

申请国别(地区):

US

年份:

2020

代理人:

摘要：

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering nucleic acids in vivo. These compositions have reduced immune activation resulting in accelerated blood clearance and/or anti-drug antibodies and they have an improved toxicity profile and therapeutic index in vivo.

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