Alan Saghatelian;Sherry Niessen;Kyle P. Chiang;Benjamin F. Cravatt
发明人:
Benjamin F. Cravatt,Kyle P. Chiang,Sherry Niessen,Alan Saghatelian
申请号：
US13585298
公开号：
US08940497B2
申请日:
2012.08.14
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and the lysophospholipids. Biochemical studies confirmed that the active protein regulates this pathway by hydrolyzing the metabolic intermediate 2-acetyl monoalkylglycerol. Inactivation of the active protein disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo.
