The Board of Regents of the University of Texas System
发明人:
Bruno Doiron,Ralph A. DeFronzo
申请号：
US14418957
公开号：
US09649344B2
申请日:
2013.07.31
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Embodiments of the invention stimulate three levels of beta cell physiology: (i) glucose metabolism, (ii) membrane receptor function, and (iii) transcriptional factors that result in the in vivo formation of beta cells in the pancreas for the purpose of treating diabetes. In certain aspects, the methods include the integration of three levels of cellular physiology: metabolism, membrane receptor function, and gene transcription. The integration of multiple levels of cellular physiology produces a synergistic effect on beta cell formation.
