PROBLEM TO BE SOLVED: To provide a novel compound inhibiting an enzyme 1-deoxy D-xylulose 5-phosphate synthase (DXS) in a 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway which mainly prokaryons have, and to provide a DXS inhibitor containing the compound.SOLUTION: There are provided: a compound represented by formula (1) wherein R is -OH or a 1-6C alkyl group, m is an integer of 0 to 3, and n is an integer of 3 to 20 and a DXS inhibitor containing the compound. The compound or the inhibitor exhibits growth inhibiting activity to related bactria (Mycobacterium smegmatis) of tubercle bacillus.COPYRIGHT: (C)2014,JPO&INPIT【課題】原核生物が主に保有している2-C-methyl-D-erythritol 4-phosphate(MEP)経路中の酵素1-deoxy D-xylulose 5-phosphate synthase(DXS)を阻害する新規化合物、及び該化合物を含有するDXS阻害剤の提供。【解決手段】下記式(1)(式(1)中、Rは、-OH基または炭素原子数1~6のアルキル基、mは、0~3の整数、nは、3~20の整数である。)で表される化合物、及び該化合物を含有するDXS阻害剤。該化合物または該阻害剤は、結核菌の類縁菌(Mycobacterium smegmatis)に対する生育阻害活性を示す。【選択図】なし
