The present invention is for the treatment, screening, judgment and prediction of cancers such as lymphoma, myeloma, leukemia, thyroid cancer, bladder cancer, breast cancer, gastric cancer, esophageal cancer, head and neck cancer and skin cancer. For monitoring the efficacy of treatment of cancer, such as lymphoma, myeloma, leukemia, thyroid cancer, bladder cancer, breast cancer, gastric cancer, esophageal cancer, head and neck cancer and skin cancer, and drug discovery Methods and compositions are provided.本発明は、癌、たとえば、リンパ腫、骨髄腫、白血病、甲状腺癌、膀胱癌、胸部癌、胃癌、食道癌、頭頸部癌および皮膚癌などのようなものの処置、スクリーニング、判断および予測のための、癌、たとえば、リンパ腫、骨髄腫、白血病、甲状腺癌、膀胱癌、胸部癌、胃癌、食道癌、頭頸部癌および皮膚癌などのようなものの処置の有効性を監視するための、および創薬のための方法および組成物を提供する。