A method and system are provided for a portable cardio-acoustic device. The device includes a display with user input, a sensor array to capture heart related vibrations from infrasound and acoustically transmitted audible sound, and a processor to extract salient features in accordance with human factor analysis, separate heart sounds as a function of sound patterns modeled from mechanical and physiological processes of the heart, classify heart sound patterns in accordance with biologically based signal processing models of the auditory cortex and cerebellum, and diagnose and monitor cardiovascular condition based on the classification of the heart sound patterns.