The present disclosure provides a method of positioning a medical device in a patient. The method includes coating a balloon with a substance, wherein the coating substance comprises at least one layer comprised at least partially of a medicinal agent and a polymer, inserting the deflated balloon into a cardiac system of the patient, placing the balloon in the proper location in the cardiac system of the patient, and inflating the balloon by injecting a sterile liquid from a syringe into the balloon. The method also includes positioning the substance proximate the tissue of the cardiac system of the patient, wherein the cardiovascular drug medicinal agent comprising the substance is drug eluting.
