The present invention provides a set of in vitro and in silico methodologies forpredicting in vivo pharmacokinetics and pharmacodynamics of multiple componentsthe methodologies comprise mathematical models for solving multiple unknownswhich are linearly independent and/or interacting with each other. The presentinvention can be applied to develop phytomedicines which contain multiple activeingredients without prior identification, isolation and purification of thesecomponents.
