STOCKLEY, MARTIN LEE,MACDONALD, ELLEN CATHERINE,SHAH, PRITOM,JORDAN, ALLAN,HITCHIN, JAMES,HAMILTON, NIALL
申请号：
CA2974266
公开号：
CA2974266A1
申请日:
2016.02.04
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to compounds of formula I, wherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.
