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SACÁRIDOS MODIFICADOS
专利权人:
GLAXOSMITHKLINE BIOLOGICALS SA
发明人:
ANGELA BARDOTTI,FRANCESCO BERTI,PAOLO COSTANTINO
申请号:
PT08737594
公开号:
PT2118145T
申请日:
2008.01.11
申请国别(地区):
PT
年份:
2017
代理人:
摘要:
Modified capsular saccharides comprising a blocking group at a hydroxyl group position on at least one of the monosaccharide units of the corresponding native capsular saccharide, wherein the blocking group is of the formula (Ia) or (Ib): -O-X-Y (Ia) or -O-R 1 (Ib) wherein X is C(O), S(O) or SO 2 ; Y is NR 1 R 2 or R 3 ; R 1 is C 1-6 alkyl substituted with 1, 2 or 3 groups independently selected from hydroxyl, sulphydryl and amine; R 2 is H or C 1-6 alkyl; and R 3 is C 1-6 alkyl; processes for modifying a capsular saccharide with the blocking groups; saccharide-protein conjugates comprising the modified capsular saccharide; processes for making the saccharide-protein conjugates, pharmaceutical compositions comprising the modified capsular saccharides and/or saccharide-protein conjugates; and methods and uses of the same.
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