Demetrios K. VASSILATIS,Athanasios D. SPATHIS,Demostenes FOKAS
申请号：
US15770162
公开号：
US20180311243A1
申请日:
2016.10.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides a series of substituted aryl pyrimidine compounds and the use of these compounds as therapeutics to treat or prevent neurodegenerative disorders, including Parkinsons disease. Compounds of the invention are also able to treat the symptoms of such diseases and therefore represent a new treatment modality for ameliorating chronic and acute conditions. The compounds of the invention are capable of selectively potentiating the activity of the Nurr1:RXRα heterodimer, and are able to treat diseases or conditions associated with aberrant Nurr1:RXRα function. The invention further provides methods for treating neurodegenerative disorders by administration of Nurr1:RXRα activating agents.
