FINCh Garri (GB),ФИНЧ Гарри (GB),REhJ Nikolas Charl'z (GB),РЭЙ Николас Чарльз (GB),BULL Richard Dzhejms (GB),БУЛЛ Ричард Джеймс (GB),VAN NIL Monik Bodil (GB),ВАН НИЛ Моник Бодил (GB),DZhENNINGZ Ehndrj,FINCH GARRI,REHJ NIKOLAS CHARLZ,BULL RICHARD DZHEJMS,VAN NIL MONIK BODIL,DZHENNINGZ EHNDRJU STEFEN ROBERT,ДЖЕНН
申请号：
RU2008108996/04
公开号：
RU0002442771C2
申请日:
2006.08.08
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention refers to new compounds of the formula (I) that are characterized by the properties of M3 muscarine receptor antagonist that is applicable in treatment or prevention of the disease or state (the abnormity of) which includes activity of the M3 muscarine receptor such as respiratory diseases. In the formula (I) A is represented by the oxygen atom or the group -N(R12)-； (i) R1 is represented by C1-C6-alkyl or the hydrogen atom； and R2 is represented by the hydrogen atom or the group -R5, -Z-Y-R5, -Z-NR9R10, -Z-NR9CO-R5 or -Z-CO2H； and R3 is absent or is represented by C1-C6-alkyl, and in this case the nitrogen atom to which it is bound is represented by tetradic nitrogen and bears a positive charge； or (ii) R1 and R2 together with nitrogen to which they are bound form heterocycloalkyl ring； the mentioned ring is displaced by the group -Y-R5 or -Z-Y-R5, and R3 is absent or is represented by C1-C6-alkyl, and in this case the nitrogen atom to which it is bound is represented by tetradic nitrogen and bears a positive charge； R4 is represented by the formula group (a), (b), (c) or (d)； Z is represented by C1-C16-alkylene group； Y is represented by the link or the oxygen atom； R5 is represented by C1-C6-alkyl, aryl, phenyl condensed with C3-C6cycloalkyl, phenyl condensed with heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, C3-C6cycloalkyl or heteroC3-C6cycloalkyl group； R6 is represented by C1-C6-alkyl or the hydrogen atom； n and m equal 0； R8a and R8b are independently chosen from the group consisting of aryl, phenyl condensed with heterocycloalkyl, heteroaryl, C1-C6-alkyl, C3-C6cycloalkyl； R8c is represented by -OH or C1-C6-alkyl； R9 and R10 are represented independently by the hydrogen atom, C1-C6-alkyl, aryl, phenyl condensed with heterocycloalkyl and other components mentioned in the invention formula.EFFECT: new compounds applicable in treatment or prevention of the disease or state (the abnormity of) w
