LABORATOIRE FRANÇAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES
发明人:
BOUREL, DOMINIQUE,JORIEUX, SYLVIE,DE ROMEUF, CHRISTOPHE,KLEIN, PHILIPPE,GAUCHET, CHRISTINE,BIHOREAU, NICOLAS
申请号：
DK04786018
公开号：
DK1648513T3
申请日:
2004.07.30
申请国别(地区):
DK
年份:
2014
代理人:
摘要：
Using a monoclonal antibody (MAb), chimeric, human or humanized, in which the glycan structure of the Fc region is of the two-branched type, to prepare a composition for treating patients with a CD16 polymorphism, partricularly V/F 158 or F/F 158, is new. Use of a monoclonal antibody (MAb), chimeric, human or humanized, in which the glycan structure of the Fc region is of the two-branched type, to prepare a composition for treating patients with a CD16 polymorphism, partricularly V/F 158 or F/F 158. The glycan structure has short chains； low degree of sialylation of mannose and GlcNAc at the terminal, non-intercalated point of attachment, and a low degree of fucosylation. Particularly patients are those for whom treatment with currently available antibodies has failed or who are suffering adverse side effects. ACTIVITY : Cytostatic； Antibacterial； Virucide； Schistomacide. No biological data given. MECHANISM OF ACTION : Ab induce secretion of cytokines (especially tumor necrosis factor； interferon-gamma ； IP 10 and interleukin-6) and antibody-dependent cellular cytotoxicity.
