Embodiment in one example, a kind of system for handling a tissue site is disclosed, including being suitable for contacting tissue site and providing the dressing of a fluid-tight between a Curing circumstance and a local external environment, and it is fluidly coupled to dressing and is suitable for conveying an antiseptic solution including a peroxide keto carboxylic acid, such as peroxy propanone acid, to the source of solvent of tissue interface. The system further include: be fluidly coupled to dressing and be suitable for after the conveying of the antimicrobial fluid of Curing circumstance provide negative pressure to Curing circumstance negative pressure source. Embodiment in another example, a kind of method for handling a tissue site is disclosed, including placing a tissue interface to contact tissue site, in the case that covering tissue interface and tissue site are in a cloth and provide a fluid-tight between Curing circumstance and local external environment, conveying includes an antiseptic solution of peroxide keto carboxylic acid to Curing circumstance, before providing negative pressure for Curing circumstance.
