NEW DERIVATIVE PURINILPIRIDINILAMINO-2,4-DIFTORFENILSULFONAMIDA, pharmaceutically acceptable salt thereof, process for its preparation and pharmaceutical compositions having inhibitory activity against the RAF-KINASE containing the present compound as an active ingredient
ШИМ Еун Кионг (KR),КИМ Нам Доо (KR),ШИМ Тае Бо (KR),КИМ Сеунг Йонг (KR)
申请号：
RU2013129993/04
公开号：
RU2013129993A
申请日:
2011.11.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A new derivative of purinylpyridinylamino-2,4-difluorophenylsulfonamide represented by the following formula 1, or a pharmaceutically acceptable salt thereof: (wherein R is a linear or branched C-C1-6alkyl； C-Cycloalkyl unsubstituted or substituted with one or more substituents selected from the group consisting of halogen and linear or branched C-C1-6alkyl； C-Saryl substituted with one or more substituents selected from the group consisting of halogen, linear or branched C-C1-6alkyl and linear or branched o C-Salkoxy substituted with linear or branched C-Salkoxy and halogen； C-Heteroaryl consisting of one or two rings, unsubstituted or substituted with one or more substituents selected from the group consisting of linear or branched C-Salkyl substituted with halogen, linear or branched C-C1-6alkyl, linear or branched C-Salkoxycarbonyl and C-Heterocycloalkyl containing one or more oxygen (O) atoms in the ring； C-Heterocycloalkyl unsubstituted or substituted by one or more substituents selected mi from the group consisting of halo and linear or branched C-alkyl； or C-Saryl linear or branched C-C1-6alkyl unsubstituted or substituted by halogen, nitro and linear or branched C-C1-6 alkyl, wherein heteroaryl and heterocycloalkyl contain in the ring one or more heteroatoms selected from the group consisting of N, O and S ) .2. The new derivative of purinylpyridinylamino-2,4-difluorophenylsulfonamide or a pharmaceutically acceptable salt thereof according to claim 1, wherein R is methyl； ethyl； drank； isopropyl； butyl； isobutyl； cyclopropyl； qi1. Новое производное пуринилпиридиниламино-2,4-дифторфенилсульфонамида, представленное приведенной далее формулой 1, или его фармацевтически приемлемая соль:(гдеR представляет собой линейный или разветвленный С-Салкил； С-Сциклоалкил, незамещенный или замещенный одним или более заместителями, выбранными из группы, состоящей из галогена и линейного или разветвленного С-Салкила； С-Сарил, замещенный одним или более заместителями, выбр
