Systems and methods convey a closure material into a catheter (20). The closure material comprises first (96) and second (100) components, which upon mixing form a solid closure material composition. The first component (96) may be a lyophilized polyethylene glycol material contained within a vial. The second (100) component may be a buffered albumin solution plus water contained within a syringe (98). An applicator provides easy and effective mixing of the components and delivery of the mixture to the puncture site.