KIM, SUNG WUK,JUN, SUNG SOO,MIN, CHANG HEE,KIM, YOUNG WOONG,KANG, MIN SEOK,OH, BYUNG KYU,PARK, SE HWAN,KIM, YONG EUN,KIM, DUCK,LEE, JI SUN,OH, JU HOON
申请号：
EP11731936
公开号：
EP2522653A4
申请日:
2011.01.06
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
A biguanide derivative compound with N4-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPK and inhibition of cancer cell proliferation in a low dose, compared with conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.
