Darell D. Bigner,Chien-Tsun Kuan,John H. Sampson,Mingqing Cai,Bryan D. Choi,Ira H. Pastan
申请号：
US13296809
公开号：
US09249217B2
申请日:
2011.11.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging molecules are highly cytotoxic and antigen-specific.
