TARGETING GLIOBLASTOMA STEM CELLS THROUGH THE TLX-TET3 AXIS

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专利权人:

City of Hope

发明人:

Yanhong Shi,Qi Cui,Su Yang

申请号：

US16824443

公开号：

US20200308585A1

申请日:

2020.03.19

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided. The modulation may comprise downregulating TLX expression and/or modulating TET3. In addition, methods of delivering shRNAs using dendrimer nanoparticles into glioblastoma stem cells are provided. The methods and compositions are useful for treating and preventing the progression of brain cancer, e.g., glioblastoma.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/