Methods to stimulate cell growth, synaptic remodeling and long-term memory consolidation

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专利权人:

ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート

发明人:

ダニエル・エル．・アルコン,ジャリン・ホンパイサン,ダニエル・エル.・アルコン

申请号：

JP2012266541

公开号：

JP6151013B2

申请日:

2012.12.05

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention provides methods of slowing or reversing the loss of memory and learning comprising the steps of contacting an effective amount of a PKC activator with a protein kinase C (PKC) in a subject identified with memory loss slowing or reversing memory loss. The present invention provides methods of stimulating cellular growth, neuronal growth, dendritic growth, dendritic spine formation, dendritic spine density, and the translocation of ELAV to proximal dendrites, and synaptic remodeling. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to stimulate the synthesis of proteins sufficient to consolidate long-term memory. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to downregulate PKC.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/