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USE OF CHAINS OF MAGNETOSOMES TO TREAT TUMORS BY HEAT THERAPY
专利权人:
NANOBACTERIE
发明人:
ALPHANDERY, EDOUARD,FAURE, STEPHANIE,CHEBBI, IMENE
申请号:
CA2780851
公开号:
CA2780851C
申请日:
2010.11.18
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
In this disclosure, we describe a method for the treatment of tumor(s) or tumor cell(s) or cancer(s) in a subject in need by the generation of heat. The latter is produced by chains of magnetosomes extracted from whole magnetotactic bacteria and subjected to an alternative magnetic field. These chains of magnetosomes yield efficient antitumoral activity whereas magnetosomes unbound from the chains or kept within the whole bacteria produce poor or no antitumoral activity. The introduction of various chemicals such as chelating agents and/or transition metals within the growth medium of the bacteria improves the heating properties of the chains of magnetosomes. Moreover, the insertion of the chains of magnetosomes within a lipid vesicle is also suggested in order to favor their rotation in vivo and hence to improve their heating capacity. The vesicle can contain an antitumoral agent together with the chains of magnetosomes. In this case, the agent is released within the tumors by heating the vesicle.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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