Solid oral formulations and crystalline forms of an inhibitor of apoptosis protein

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专利权人:

Novartis AG

发明人:

THAKUR, Jeewan,YANG, Dong,FENG, Lili

申请号：

AU2017254950

公开号：

AU2017254950B2

申请日:

2017.11.03

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

#$%^&*AU2017254950B220180920.pdf#####I: dar Intrwovn NRPortbl DCC DAR 15950483_I.DOC-2 /t12017 ABSTRACT The present disclosure relates to crystalline form of (S)-N-((S)-1-cyclohexyl-2-{(S)2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylaminopropionamide, salts and hydrates thereof. This disclosure also relates to solid oral formulation of (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]pyrrolidin-1 -yl}-2-oxo-ethyl)-2-methylamino-propionamide, pharmaceutically acceptable salts, solvates (including hydrates) thereof, as well as methods of treatment using the same.

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