Sun Hwa Kim,Ji Hoon Jeong,Tae-il Kim,Sung Wan Kim,David A. Bull
申请号：
US12496568
公开号：
US08153155B2
申请日:
2009.07.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with siRNA. ABP is biodegraded under reducing conditions, such as in the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity. ABP is an effective delivery vehicle for gene silencing with siRNA and may be used for treating cancer.
