The present application relates to a patient interface structure (20) for delivery of respiratory therapy to a patient, comprising a front plate (21) configured to conform to the shape of the patient's face. The patient interface structure further comprises a mouth cushion (24) defining a breathing chamber and provided to the front plate and configured to seal around the patient's mouth, a nasal cushion (24) configured to seal around the patient's nares, and headgear (30) comprising a headgear strap (32, 34, 35) and a clip (299,303,304) configured to interface with the front plate. The nasal cushion is supported by the mouth cushion; wherein the nasal cushion does not contact a bridge of the patient's nose in use. The mouth cushion comprises a front portion adapted to receive the front plate and a rear portion comprising at least one flap (232) or membrane configured to seal against the patient's face. The front plate has a comparatively greater rigidity than the mouth cushion. The headgear is configured to deliver gases to the face plate through the clip.