Jay A. Berzofsky,Yi-Hsiang Huang,Masaki Terabe,Ira H. Pastan
申请号：
US14496194
公开号：
US09394352B2
申请日:
2014.09.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
POTE has recently been identified as a tumor antigen expressed in a variety of human cancers, including colon, ovarian, breast, prostate, lung and pancreatic cancer. Described herein are immunogenic POTE polypeptides, including modified POTE polypeptides, that bind MHC class I molecules. The immunogenic POTE polypeptides are capable of inducing an immune response against POTE-expressing tumor cells. Thus, provided herein is a method of eliciting an immune response in a subject, such as a subject having a type of cancer that expresses POTE.
