Systems and methods for cleaning teeth by removal of dental biofilm. In one illustrative embodiment, a custom fit tray that fits over the teeth and seals against the gum of a mammal. A number of ports are embedded in the tray, each in fluid communication with a hose or line supplied with either a vacuum or an irrigant/fluid source. A small space between the tray and the teeth provides for fluid to flow around the teeth. A router may be connected to both an irrigant fluid supply reservoir and a vacuum pump to direct either fluid or vacuum to the various hoses with the routing changing over time for optimum cleaning. Air may be injected into the cleaning fluid in varying amounts, to create bubbles, water droplets, and/or boluses of the cleaning fluid to increase and focus the hydrodynamic forces of the fluid upon reaching the teeth.
