Romulus Kimbro Brazzell,George N. Lambrou,Elisabeth Latour,Anna Ottlecz,Jeanette Marjorie Wood
申请号：
US13593959
公开号：
US20120322874A1
申请日:
2012.08.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides a method of treating an angiogenesis-mediated ocular disorder, e.g. ocular neovascularisation, retinal neovascularisation, including neovascularisation following injury or infection, retrolental fibroplasias, and neovascular glaucoma, age-related macular degeneration, diabetic retinopathy, pathologic myopia, ocular histoplasmosis, neovascular glaucoma, retinopathy of prematurity, the after effects of corneal transplantation, control of postsurgical ocular inflammation (e.g. after cataract surgery), cystoid macular edema (CME), herpes keratitis, in a subject in need of such treatment which comprises administering to the subject an effective amount of a COX-2 inhibitor of formula Iwherein R, R1, R2, R3, R4, and R5 are as defined a pharmaceutically acceptable salts thereof or a pharmaceutically acceptable prodrug esters thereof.
