Spiro-((4-amino-cyclohexane)-1,1'-1',3',4',9'-tetrahydropyrano-(3,4-b)-indole) derivatives (I) are new. Spiro-cyclic cyclohexylamine derivatives of formula (I), optionally in the form of racemates, pure stereoisomers (especially enantiomers or diastereomers) or their mixtures in all proportions, including free bases, free acids, salts (specifically acid or base addition salt) or solvates (specifically hydrates), are new. R1, R2 = H, optionally unsaturated, optionally mono- or polysubstituted 1-4C alkyl or CHO； R3 = -(CH2)n-Aryl； n = 0-2； R4 = H, optionally unsaturated, optionally mono- or polysubstituted 1-3C alkyl or -CO-(CH2)m-H； m = 0-2； R5 - R8 = H； 1-5C alkyl or 1-3C alkoxy (both optionally unsaturated and optionally mono- or polysubstituted)； or halo, OH, SH, SMe, OMe, NH2, COOH, COOMe, NHMe, NMe2 or NO2.
