A cancer determination apparatus (1) includes a Betti number calculation section (42) for calculating, in a captured image (i) in which a tissue is captured and (ii) which has been binarized by use of a prescribed reference value as a threshold, (I) the number of connected components and (II) the number of spaces, each of the connected components being an aggregate of at least one component which is defined by connecting an outer edge(s) of the at least one component which is a graphic having a closed outer edge, each of the spaces being surrounded by an outer edge(s) of the at least one component, a comparison value calculation section (43) for calculating a comparison value indicating a difference between the number of connected components and the number of spaces, and a determination section (44) for determining, by comparing the comparison value thus calculated with a predetermined reference value, whether or not an image of a cancer tissue is included in the captured image.