The Brigham and Women's Hospital, Inc.;Massachusetts Institute of Technology;Novo Nordisk A/S
发明人:
Traverso, Carlo Giovanni,Abramson, Alex G.,Caffarel Salvador, Ester,Roxhed, Niclas,Khang, Minsoo,Bensel, Taylor,Langer, Robert S.,Water, Jorrit Jeroen,Frederiksen, Morten Revsgaard,Kristiansen, B
申请号:
AU2018269711
公开号:
AU2018269711A1
申请日:
2018.05.17
申请国别(地区):
AU
年份:
2019
代理人:
摘要:
Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).