A hybrid hydrogel including a hydrogel material and a plurality of first hybrid nanoparticles is provided. The plurality of first hybrid nanoparticles are conjugated to the hydrogel material, wherein each of the first hybrid nanoparticles includes a first positive-charged polysaccharide and a first negative-charged polysaccharide. The first positive-charged polysaccharide is located at an inner core of the first hybrid nanoparticle. The first negative-charged polysaccharide is located at an outer shell of the first hybrid nanoparticle and carries a plurality of first growth factors. The first negative-charged polysaccharide and the first positive-charged polysaccharide are electrostatically attracted to form the first hybrid nanoparticles. A method of fabricating the hybrid hydrogel is also provided.本發明提供一種複合水膠。複合水膠包括水膠材料以及多個第一複合奈米粒子。多個第一複合奈米粒子接合於水膠材料上，其中每個第一複合奈米粒子包括第一帶正電多醣以及第一帶負電多醣。第一帶正電多醣位於第一複合奈米粒子的內核。第一帶負電多醣位於第一複合奈米粒子的外殼且負載多個第一生長因子，其中第一帶負電多醣以及第一帶正電多醣以靜電作用吸引而形成第一複合奈米粒子。本發明亦提供一種複合水膠的製備方法。
