Use of proteolysis resistant active VEGF

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专利权人:

Gereon Lauer;Stephan Sollberg;Sabine Eming;Thomas Krieg

发明人:

Sabine Eming,Thomas Krieg,Stephan Sollberg,Gereon Lauer

申请号：

US12349531

公开号：

US08168590B2

申请日:

2009.01.07

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The invention relates to vascular endothelial growth factor (VEGF) in which the alanine at AA position 111 is replaced by proline. The arginine at AA position 110 may moreover be replaced by another amino acid. The invention also relates to derivatives of the VEGF according to the invention, nucleic acids, expression systems, medicaments and the use of the VEGF mutants of the invention for the treatment of chronic wounds.

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中国工程科技知识中心

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